2013 Fiscal Year Final Research Report
Effects of immune cells on inflammatory responses and oxidative stress in the exercise-induced muscle damage
| Project/Area Number |
24650410
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Sports science
|
|---|
| Research Institution | Waseda University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | 筋損傷 / 好中球 / 単球 / マクロファージ / 接着分子 / サイトカイン / MCP-1 / 炎症 |
|---|
| Research Abstract |
Although exercise induces muscle damage, the underlying mechanisms are not fully understand. The present study examined the involvement of neutrophils and macrophages in the exhaustive exercise-induced acute muscle damage in mice by application of the inhibitory neutrophil migration model and macrophage depletion model. The administlation of anti-neutrophil antibody inhibited the infiltration of Ly-6G positive cells (neutrophils) in the gastrocnemius, and the administration of clodronate liposome reduced the infiltration of F4/80 positive cells (macrophages) and related inflammatory reactions. Therefore, it was demonstrated that neutrophils and macrophages are involved in the exercise-induced muscle damage.
|
