2014 Fiscal Year Final Research Report
A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles
| Project/Area Number |
24650412
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Sports science
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | ナットウキナーゼ / 血液凝固系因子 / 血液線溶系因子 / 血栓 |
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| Outline of Final Research Achievements |
Our aim was to determine the quantitative effects of a single-dose of Nattokinase (NK) administration on coagulation/fibrinolysis parameters comprehensively in healthy male subjects. A double-blind, placebo-controlled cross-over NK intervention study was carried out in 15 healthy young males. Following the baseline blood draw, each subject was randomized to receive either a single-dose of 2,000 FU NK or placebo with subsequent cross-over of the groups. Subjects donated blood samples at 2, 4, 6 and 8 hours following administration. As a result, D-dimer concentrations and blood fibrin/fibrinogen degradation products after NK administration elevated significantly. Factor VIII activity declined, blood antithrombin concentration was higher, and the activated partial thromboplastin time prolonged significantly following NK administration. In conclusion, thus, a single-dose of NK administration appears enhancing fibrinolysis and anti-coagulation via several different pathways simultaneously.
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| Free Research Field |
スポーツ医学
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