2013 Fiscal Year Final Research Report
Epigenomic modification by stress related nutrients
| Project/Area Number |
24650423
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied health science
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| Research Institution | The University of Tokushima |
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Principal Investigator |
TAKEDA EIJI 徳島大学, ヘルスバイオサイエンス研究部, 教授 (00144973)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ストレス飾 / エピゲノム修 / 栄養 / 心身の健康 |
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| Research Abstract |
Adverse early nutrition leads to metabolic aberrations in adulthood. We investigated gestational dietary intake and its influences on metabolism in offspring. Three groups of pregnant Sprague-Dawley rats were fed either AIN63G standard diet as control, isocaloric high fat sucrose diet or calorie restriction diet (50% of control) until delivery. All dams were fed control diet ad libitum during lactation. Offsprings' metabolic parameters were assessed at three weeks. Visceral fat and plasma triglycerides of high fat sucrose diet offspring were significantly higher than those of control diet and calorie restriction diet offspring. Significant inductions of hepatic mRNA expression of stearoyl-CoA desaturase1 and delta-5 desaturase genes, were observed in high fat sucrose diet and calorie restriction diet offspring. Gestational high sugar and fat intake even without over energy intake would be more detrimental to metabolisms of offspring compared to calorie restriction.
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