2014 Fiscal Year Final Research Report
Application of acupuncture on parasympathetic nerve activation on diabetes mellitus and heart failure
| Project/Area Number |
24650438
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | Tsukuba University of Technology |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 心不全 / 糖尿病 / 自律神経 / 副交感神経 / 鍼 / 心拍変動 / 高周波数電位 / ラット |
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| Outline of Final Research Achievements |
The pathophysiology of heart failure is characterized by hemodynamic abnormalities that result in neurohormonal activation and autonomic imbalance with increase in sympathetic activity and withdrawal of vagal activity. To improve this autonomic nervous imbalance in heart failure, electrical intervention that stimulates vagus nerve directly by implantable stimulator. However, this method is expensive and invasive for the patients. Acupuncture for “Zusanli” is known to have an effect as sympathetic nerve suppression in patients with hypertension. In this study, electrical stimulation by acupuncture (EA) on “Zusanli” was employed for several rat heart failure models. As a result, improvement of parasympathetic nerve activity was suspected by EA on “Zusanli” even in severe condition of rat heart failure model.
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| Free Research Field |
総合領域
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