2013 Fiscal Year Final Research Report
Development of preventive strategy for lifestyle-related diseases by activation of circadian clock
| Project/Area Number |
24650446
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied health science
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| Research Institution | Kyushu University |
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Principal Investigator |
KOYANAGI SATORU 九州大学, 薬学研究科(研究院), 准教授 (60330932)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 体内時計 / 生活習慣病 / 加齢・老化 / 発がん |
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| Research Abstract |
Dysfunction of circadian clock along with aging is implicated with development of lifestyle-related diseases, such as diabetes, cancers, and cardiovascular diseases. However, there was no preventive strategy for lifestyle-related diseases by activation of circadian clock. In this study, we found that ATF4, a circadian clock-regulatory factor, regulates cellular oncogenic transformation and the sensitivity of tumor cells. In addition, control of the activity of ATF4 enabled to prevent oncogenesis. Since ATF4 was also involved in the regulation of amino acid synthesis and cellular senescence, control of the activity of ATF4 may lead to develop the preventive method for lifestyle-related diseases through activating the circadian clock.
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