2013 Fiscal Year Final Research Report
Light-nutritional treatment for circadian disruption using functional nutrition
| Project/Area Number |
24650490
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Kyushu University |
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Principal Investigator |
FURUSE Mitsuhiro 九州大学, (連合)農学研究科(研究院), 教授 (30209176)
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| Co-Investigator(Kenkyū-buntansha) |
YASUO Shinobu 九州大学, 大学院農学研究院, 准教授 (30574719)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 生活リズム / 概日時計 / アミノ酸 / 栄養 / 時計遺伝子 |
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| Research Abstract |
Disruption of the circadian clock by irregular illumination in the modern world causes many diseases, including sleep disorders, obesity, diabetes, hypertension, and cancer. It is important to identify the nutritional factors that can modulate the properties of the circadian clock. This study identified the functional amino acids that can modulate the activity rhythm or expression of clock genes in the brain and peripheral organs. This study further confirmed the utility of these amino acids for clock-related diseases using animal models. These data highlight the importance of amino acid nutrition for the regulation of the circadian disruption.
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[Journal Article] Photoperiodic responses of depression-like behavior, the brain serotonergic system, and peripheral metabolism in laboratory mice2014
Author(s)
Otsuka T, Kawai M, Togo Y, Goda R, Kawase T, Matsuo H, Iwamoto A, Nagasawa M, Furuse M, Yasuo S
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Journal Title
Psychoneuroendocrinology
Volume: 40
Pages: 37-47
DOI
Peer Reviewed
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[Presentation] Antidepressant-like effects of acute and chronic L-serine treatment in Wistar and Kyoto rats
Author(s)
Nagasawa, M, Otsuka T, Togo Y, Yamanaga M, Yoshida J, Yamasaki I, Uotsu N, Teramoto S, Yasuo S, Furuse, M
Organizer
International Conference and Exhibition on Nutraceuticals and Functional Foods
Place of Presentation
Kona, Hawaii, USA
Year and Date
00001200
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