Deficiency of calcium in childhood increases the risk of obesity and metabolic syndrome after growth

2015 Fiscal Year Final Research Report

• Project/Area Number: 24650499
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Eating habits, studies on eating habits
• Research Institution: Shokei Gakuin College
• Principal Investigator: Hoshi Seiko 尚絅学院大学, 総合人間科学部, 教授 (30564968)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: カルシウム不足 / 内臓脂肪 / 脂質代謝異常 / メタボリックシンドローム / 肝臓脂質 / 肥満 / ラット

Outline of Final Research Achievements

It was studied the effect on the lipid metabolism of the rats fed a low-Ca diet. In growth period, Ca deficiency inhibited significantly growth such as reduction of bone mass and loss of lean body mass. Then, plasma free fatty acid concentration was increased, lipid accumulation in the liver was induced.
In Japan, since the school age to consume milk in school meals, Ca intake has been relatively satisfied. However, Ca intake is drastically reduced for not eating school meals after the 15-year-old. Such a model the Ca intake situation of Japan was experiment. Rats in the growth phase had eaten a standard Ca diet, were given a low-Ca- high lipid energy diet after growth. Calcium deficiency of later growth was studied the effect on lipid metabolism. By the lack of Ca intake, the negative effect on the lipid metabolism were observed such as increased amount of visceral fat, rise in fasting plasma TG concentration, liver lipid accumulation and reduction of HDL cholesterol concentration.

Free Research Field

栄養学