Analyzing Fetal Origin of Adult Diseases Theory using Caenorhabditis elegans.

2013 Fiscal Year Final Research Report

• Project/Area Number: 24650507
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Eating habits, studies on eating habits
• Research Institution: Kyoto Women's University
• Principal Investigator: MATSUMOTO Shinya 京都女子大学, 家政学部, 准教授 (30263156)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 線虫 / Caenorhabditis elegans / 成人病胎児期起源説 / 低出生体重 / エピジェネティクス / 飢餓

Research Abstract

Fetal-Origin of Adult Diseases (FOAD) has been suggested as the third factor, in addition to genetic and environmental, that contributes to the establishment of life-style related disease. The basis of the theory is that nutritional condition in early stage of life may trigger the epigenetic modification in the genome, which leads to obese in adult stage. The precise mechanism of the theory, however, remains to be understood. This project was performed to explore the usefulness of Caenorhabditis elegans as a model system to study the FOAD.
In this project, it was shown that the progeny of starvation-experienced worms accumulated more fat compared to those of normally-fed worms using fluorescent dye Nile Red. The actual fat content, determined by gas chromatography, supported the increment of fat in the second generation of starvation-experienced worms. These data indicates that worms can be a suitable model system to study FOAD theory.

Research Products

• [Journal Article] Non-specific Protein Modifications by a Phytochemical Induce Heat Shock Response for Self-Defense (2013)
  • Author(s): Kohta Ohnishi, Shinya Ohkura, Erina Nakahata, Akira Ishisaka, Yoshichika Kawai, Junji Terao, Taiki Mori, Takeshi Ishii, Tsutomu Nakayama, Noriyuki Kioka, Shinya Matsumoto, Yasutake Ikeda, Minoru Akiyama, Kazuhiro Irie, Akira Murakami
  • Journal Title: PLOS ONE Volume: 8 Pages: 1-15
  • Peer Reviewed
• [Journal Article] 長期的な酸化脂質摂取が線虫の生殖能力と寿命に与える影響 (2012)
  • Author(s): 木村理恵, 麻生知子, 相馬顕子, 森友彦, 松村康生, 松本晋也
  • Journal Title: 京都女子大学食物学会誌 Volume: 67 Pages: 37-44
  • Peer Reviewed
• [Presentation] Effect of repeated starvation on fat content in C.elegans (2013)
  • Author(s): Shinya Matsumoto, Kosuke Kato, Yasuki Matsumura, Nao Sato, Yukari Yamamoto, Akari Sawanaga
  • Organizer: 19th International C.elegans Meeting
  • Place of Presentation: UCLA(Los Angeles, USA)
  • Year and Date: 20130726-30
• [Book] 健康と環境の科学, 担当執筆第1章2節 (2014)
  • Author(s): 有園幸司, 石橋弘志, 石橋康弘, 伊藤貴美子, 岡本誉士典, 甲斐穂高, 古賀伸幸, 柴田祥江, 杉原数美, 高尾雄二, 瀧口益史, 春山洋一, 松原斎樹, 松本晋也, 山元涼子, 川添貞治(編)
  • Publisher: 講談社
• [Book] 新食品・栄養科学シリーズ基礎栄養学, 執筆担当第10章, 第11章 (2012)
  • Author(s): 松本晋也, 他多数, 灘本知憲, 仲佐輝子(共編)
  • Publisher: 化学同人
• [Remarks] 京都女子大学家政学部食物栄養学科松本晋也
  • URL: http://gyouseki-db.kyoto-wu.ac.jp/2/0000128/profile.html