2013 Fiscal Year Final Research Report
Does activation of AMPK in the kidney by food components ameliorate IgA nephropathy?
| Project/Area Number |
24650509
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Beppu University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 栄養学 / 食品成分 / IgA腎症 / AMPK |
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| Research Abstract |
The aims of the present study were to determine whether adenosine-5'-monophosphate (AMP) and resveratrol (RSV) activate AMP-activated protein kinase (AMPK) in the renal tissues and improve progression in IgA nephropathy of mice. AMP and RSV treatments declined levels of plasma creatinine, amounts of urinary albumin excretion, and accumulation of glomerular mesangial matrix in IgA nephropathy mice, while attenuated reduction of total and phosphorylated AMPK expressions in the kidneys. In addition, AMP treatment decreased levels of proinflammatory cytokine, TNF-alpha in the renal tissues.
Taken together, these results suggest that AMP and RSV might have the renoprotective effects through the activation of AMPK in the renal tissues of IgA nephropathy mice.
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