2013 Fiscal Year Final Research Report
The molecular mechanism of nuclear pore proteins and leukemogenesis
| Project/Area Number |
24650611
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Carcinogenesis
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| Research Institution | Kanazawa University |
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Principal Investigator |
WONG W・RICHARD 金沢大学, 自然システム学系, 教授 (30464035)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 核膜孔複合体 / Rae1 / Nup98 / JARID1A / 白血病 / エピジェネティクス / トランスジェニックマウス / 転写因子 |
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| Research Abstract |
Nuclear pore complexes are embedded in the nuclear envelope and act as molecular sieves, selectively facilitating the transport of proteins and RNA in and out of the nucleus. Recently, we showed that NUP98 binding partner, RAE1 involved in the development of NUP98-HOXA9 leukemogenesis. We want to investigate epigenetic mechanism in carcinogenesis through a novel approach of nucleoporins-histone modifiers orchestration. We also plan to compare the difference between the difference of NUP98 fusions, HOX genes (NUP98-HOXA9) and those fusions with PHD domain (NUP98-JARID1A). Through this grant support, we have generated NUP98-JARID1A mice. We are still investigating the NUP98-JARID1A and the leukemogenesis via this mice. Meanwhile, we also published several related NPC papers and presented some of our data in the international and domestic conferences.
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[Journal Article] Shiragawa M and Kondo N, TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD882012
Author(s)
Ohnishi H@, Tochio H@, Kato Z, Kawamoto N, Kimura T, Kubota K, Yamamoto T, Funasaka T, Nakano H, Wong RW
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Journal Title
PLoS ONE
Volume: 7(6)
Pages: e38423
DOI
Peer Reviewed
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