2013 Fiscal Year Final Research Report
The role of CDX1 in malignant progression of intestinal tumorigenesis
| Project/Area Number |
24650619
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Tumor biology
|
|---|
| Research Institution | University of Fukui |
|---|
Principal Investigator |
AOKI Koji 福井大学, 医学部, 教授 (40402862)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | 大腸癌 / 悪性化 / 幹細胞性 |
|---|
| Research Abstract |
I found that CDX1 and CDX2, intestine-specific transcription factors, suppressed malignant progression of intestinal tumorigenesis. Importantly, CDX1 and CDX2 appeared to inhibit stemness of intestinal tumors, suggesting they were novel suppressors of stemness of colon cancer cells.
We are going to reveal the mechanisms of controlling stemness of colon cancer cells, aiming to identify therapeutic targets to kill colon cancer stem cells.
|
Research Products
(4 results)
-
[Journal Article] In situ differentiation of CD8ααT cells from CD4 T cells in peripheral lymphoid tissues2012
Author(s)
Nambu Y, Hayashi T, Jang KJ, Aoki K, Mano H, Nakano K, Osato M, Takahashi K, Itoh K, Teramukai S, Komori T, Fujita J, Ito Y, Shimizu A, Sugai M
-
Journal Title
Scientific Reports
Volume: 2
Pages: 642
Peer Reviewed
-
[Presentation] Roles of intestine-specific homeoprotein CDX2 in the intestinal epithelial barrier2013
Author(s)
Aoki K, Iemura S, Okawa K, Tanida I, Kobayashi T, Mimuro H, Takahito S, Sasakawa C, Natume T, Sugai M, Taketo MM
Organizer
ST-CREST International Symposium, Frontiers in Immunology and Inflammation : From Molecules to Disease
Place of Presentation
Tokyo
Year and Date
2013-02-13
-
-
