2013 Fiscal Year Final Research Report
Mechanism of tumorigenesis in mast cells
| Project/Area Number |
24650623
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor biology
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
ABE Ryo 東京理科大学, 生命医科学研究所, 教授 (20159453)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | がん細胞の特性 / マスト細胞 / 腫瘍化 / STAT5 / Akt |
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| Research Abstract |
Mast cells have an important role in immune responses. Their proliferation is tightly regulated by various receptors that bind to cytokines. It is well known that constitutively activations of the receptors lead to mast cell tumors. However, the precise mechanism of the tumorigenesis of mast cells is not fully understood. Recently, we established a mast cell lines that have characteristic features of a mast cell tumor. Using microarray analyses and biochemical analyses, we obtained some novel findings about the process of mast cell tumorigenesis.
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