2013 Fiscal Year Final Research Report

Analysis of sex hormones derived signaling in lung cancer

Research Project

Project/Area Number	24650624
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Single-year Grants
Research Field	Tumor biology
Research Institution	University of Occupational and Environmental Health, Japan
Principal Investigator	INOUE Masaaki 産業医科大学, 医学部, 非常勤医師 (20330988)
Project Period (FY)	2012-04-01 – 2014-03-31
Keywords	ATBF1(ZFHX3) / 肺癌 / 性ホルモン
Research Abstract	The purpose of this study was to evaluate that sex hormones is involved in the etiology of lung cancers through ATBF1 signaling pathway. High expression of AFBF1 in lung cancer cells showed positive relation to the ERalpha expression. From those results ERalpha signaling can also affect ATBF1 signaling in lung cancer, and those signaling system could involved in prognosis of lung cancer. Next, it is necessary to evaluate whether the ERalpha-ATBF1 signaling involve the sex difference of prognosis using large number of clinical samples, and also analyze the signaling pathway directly in vitro.

(1 results)