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2013 Fiscal Year Final Research Report

Bioinformatics-based functional analysis of telomeric non-coding RNA

Research Project

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Project/Area Number 24650639
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Tumor diagnosis
Research InstitutionJapanese Foundation for Cancer Research

Principal Investigator

SEIMIYA Hiroyuki  公益財団法人がん研究会, がん化学療法センター分子生物治療研究部, 部長 (50280623)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywordsテロメア / 非コードRNA / がん / バイオインフォマティクス / 分化
Research Abstract

Telomeres are specialized structures that stabilize the genome at the ends of linear chromosomes. Recently, it has been reported that telomeric DNAs are transcribed to non-coding RNAs called TERRA. Since the precise importance of TERRA remains unknown, here we investigated the function of TERRA especially in human cancer cells. As the results, we found that cancer cells with more TERRA expression decrease the expression of protein X, which regulates the growth signal elicited by tyrosine phosphorylation. Telomere elongation enhanced TERRA expression and induced differentiation of cancer cells. These results suggest that TERRA regulates its expression upon the change in telomeric structure and modulates the cancer malignancy. These observations may be utilized for cancer diagnosis and therapeutics.

  • Research Products

    (21 results)

All 2013 2012 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (9 results) (of which Invited: 4 results) Book (3 results) Remarks (1 results)

  • [Journal Article] Telomere length influences cancer cell differentiation in vivo2013

    • Author(s)
      Hirashima, K., Migita, T., Sato, S., Muramatsu, Y., Ishikawa, Y., Seimiya, H.
    • Journal Title

      Mol Cell Biol

      Volume: 33 Pages: 2988-2995

    • DOI

      10.1128/MCB.00136-13

    • Peer Reviewed
  • [Journal Article] Evaluation of the interaction between long telomeric DNA and macrocyclic hexaoxazole (6OTD) dimer of a G-quadruplex ligand2013

    • Author(s)
      Iida, K., Majima, S., Nakamura, T., Seimiya, H., Nagasawa, K.
    • Journal Title

      Molecules

      Volume: 18 Pages: 4328-4341

    • DOI

      10.3390/molecules18044328

    • Peer Reviewed
  • [Journal Article] Interaction of long telomeric DNAs with macrocyclic hexaoxazole as a G-quadruplex ligand2013

    • Author(s)
      Iida, K., Tsubouchi, G., Nakamura, T., Majima, S., Seimiya, H., Nagasawa, K.
    • Journal Title

      Med Chem Commun

      Volume: 4 Pages: 260-264

    • DOI

      10.1039/C2MD20234D

    • Peer Reviewed
  • [Journal Article] Development of a gene expression database and related analysis programs for evaluation of anticancer compounds2013

    • Author(s)
      Ushijima M., Mashima, T., Tomida, A., Dan, S., Saito, S., Furuno, A., Tsukahara, S., Seimiya, H., Yamori, T., Matsuura, M.
    • Journal Title

      Cancer Sci

      Volume: 104 Pages: 360-368

    • DOI

      10.1111/cas.12071

    • Peer Reviewed
  • [Journal Article] A caged ligand for a telomeric G-quadruplex2012

    • Author(s)
      Nakamura T., Iida, K., Tera, M., Shin-ya, K., Seimiya, H., Nagasawa, K.
    • Journal Title

      Chembiochem

      Volume: 13 Pages: 774-777

    • DOI

      10.1002/cbic.201200013

    • Peer Reviewed
  • [Journal Article] Telomestatin impairs glioma stem cell survival and growth through the disruption of telomeric G-quadruplex and inhibition of the proto-oncogene, c-Myb2012

    • Author(s)
      Miyazaki T., Pan, Y., Joshi, K., Purohit, D., Hu, B., Demir, H., Mazumder, S., Okabe, S., Yamori, T., Viapiano, M., Shin-ya, K., Seimiya, H., Nakano, I.
    • Journal Title

      Clin Cancer Res

      Volume: 18 Pages: 1268-1280

    • DOI

      10.1158/1078-0432.CCR-11-1795

    • Peer Reviewed
  • [Journal Article] HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle2012

    • Author(s)
      Deardorff M. A., Bando, M., Nakato, R., Watrin, E., Itoh, T., Minamino, M., Saitoh, K., Komata, M., Katou, Y., Clark, D., Cole, K. E., De Baere, E., Decroos, C., Di Donato, N., Ernst, S., Francey, L. J., Gyftodimou, Y., Hirashima, K., Hullings, M., Ishikawa, Y., Jaulin, C., Kaur, M., Kiyono, T., Lombardi, P. M., Magnaghi-Jaulin, L., Mortier, G. R., Nozaki, N., Petersen, M. B., Seimiya, H., Siu, V. M., Suzuki, Y., Takagaki, K., Wilde, J. J., Willems, P. J., Prigent, C., Gillessen-Kaesbach, G., Christianson, D. W., Kaiser, F. J., Jackson, L. G., Hirota, T., Krantz, I. D., Shirahige, K.
    • Journal Title

      Nature

      Volume: 489 Pages: 313-317

    • DOI

      10.1038/nature11316

    • Peer Reviewed
  • [Journal Article] TRF1 ensures the centromeric function of Aurora-B and proper chromosome segregation

    • Author(s)
      Ohishi, T., Muramatsu, Y., Yoshida, H., Seimiya, H.
    • Journal Title

      Mol Cell Biol

      Volume: (in press)

    • DOI

      10.1128/MCB.00161-14

    • Peer Reviewed
  • [Presentation] TRF1 regulates the microtubule-kinetochore attachment and contributes to proper chromosome segregation2013

    • Author(s)
      Seimiya, H.
    • Organizer
      1st International Symposium on Protein Modifications in Pathogenic Dysregulation of Signaling
    • Place of Presentation
      東京
    • Year and Date
      20130201-02
  • [Presentation] テロメア配列はヒトがん細胞の遺伝子発現を制御する2013

    • Author(s)
      平島匡太郎、清宮啓之
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2013-12-03
  • [Presentation] Telomere length influences cancer cell differentiation in vivo2013

    • Author(s)
      Seimiya H.
    • Organizer
      The 3rd GDRI French Japanese Cancer Meeting
    • Place of Presentation
      Toulouse, France
    • Year and Date
      2013-11-20
    • Invited
  • [Presentation] 抗がん剤探索アプローチの変遷と最近の話題2013

    • Author(s)
      清宮啓之
    • Organizer
      第72回日本癌学会学術総会モーニングレクチャー
    • Place of Presentation
      横浜
    • Year and Date
      2013-10-05
    • Invited
  • [Presentation] TRF1 ensures proper chromosome segregation in mitosis2013

    • Author(s)
      Seimiya, H., Ohishi, T., Muramatsu, Y.
    • Organizer
      Cold Spring Harbor Laboratory Meeting on Telomeres & Telomerase
    • Place of Presentation
      Cold Spring Harbor, NY, USA
    • Year and Date
      2013-05-02
  • [Presentation] テロメア長が腫瘍内遺伝子発現に及ぼす影響2012

    • Author(s)
      平島匡太郎、右田敏郎、佐藤重男、石川雄一、清宮啓之
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      20121211-14
  • [Presentation] TRF1 regulates the microtubule-kinetochore attachment and contributes to proper chromosome segregation2012

    • Author(s)
      Seimiya, H., Ohishi, T., Muramatsu Y.
    • Organizer
      EMBO Conference on Telomeres and the DNA Damage Response
    • Place of Presentation
      L'Isle sur la Sorgue, France
    • Year and Date
      20121002-06
  • [Presentation] がん研究基礎セミナー「新薬の原石をもとめて〜抗がん剤・化合物スクリーニング〜」2012

    • Author(s)
      清宮啓之
    • Organizer
      平成24年度がん若手研究者ワークショップ
    • Place of Presentation
      蓼科
    • Year and Date
      20120905-08
    • Invited
  • [Presentation] Regulation of chromosome segregation by a telomeric protein2012

    • Author(s)
      Seimiya, H.
    • Organizer
      The 11th Korea-Japan-Germany Joint Symposium on Cancer and Ageing Research
    • Place of Presentation
      Gyeongju, Korea
    • Year and Date
      20120705-07
    • Invited
  • [Book] ノーベル賞をもたらしたテロメア研究と癌の診断・治療応用への期待、Surgery Frontier 202013

    • Author(s)
      清宮啓之
    • Total Pages
      37-43
    • Publisher
      メディカルレビュー社
  • [Book] 癌細胞の不死化と難治性、臨牀と研究902013

    • Author(s)
      清宮啓之
    • Total Pages
      20-26
    • Publisher
      大道学館出版部
  • [Book] テロメアの維持と細胞の分裂寿命、「がん増殖と悪性化の分子機構」2012

    • Author(s)
      清宮啓之(編者:宮澤恵二・伊東進)
    • Total Pages
      56-67
    • Publisher
      化学同人
  • [Remarks]

    • URL

      http://www.jfcr.or.jp/chemotherapy/department/molecular_biotherapy/index.html

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Published: 2015-06-25  

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