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2013 Fiscal Year Final Research Report

Biological monitoring system for detection of environmental stress.

Research Project

  • PDF
Project/Area Number 24651048
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Risk sciences of radiation/Chemicals
Research InstitutionOsaka University

Principal Investigator

TODO Takeshi  大阪大学, 医学(系)研究科(研究院), 教授 (90163948)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords損傷応答 / 放射線 / 化学変異原 / メダカ
Research Abstract

Detection of the environmental pollution is an emerging issue having strong social demand. In this proposal, we proposed establishment of a biological monitoring system for DNA damaging agents, which include radiation and chemical mutagens. Medaka is a small experimental model fish and very suitable for field experiments. We tried to establish a medaka line, which produces fluorescent light responding to DNA damage.

  • Research Products

    (11 results)

All 2014 2013 2012 Other

All Journal Article (4 results) Presentation (6 results) (of which Invited: 1 results) Remarks (1 results)

  • [Journal Article] Imaging plant leaves to determine changes in radioactive contamination status in Fukushima, Japan2014

    • Author(s)
      Nakajima H, Fujiwara M, Tanihata I, Saito T, Matsuda N, Todo T
    • Journal Title

      Health Phys.

      Volume: 106(5) Pages: 565-70

    • DOI

      10.1097/HP.0000000000000020

  • [Journal Article] p53-Dependent Suppression of Genome Instability in Germ Cells2014

    • Author(s)
      Otozai S, Ishikawa-Fujiwara T, Oda, S, Kamei Y, Ryo H, Sato A, Nomura T, Mitani H, Tsujimura T, Inohara H, and Todo T
    • Journal Title

      Mutat Res.

      Volume: 760 Pages: 24-32

    • DOI

      10.1016/j.mrfmmm.2013.12.004

  • [Journal Article] Mitotic slippage underlies the relationship between p53 dysfunction and the induction of large micronuclei by colcemid2013

    • Author(s)
      Hashimoto K, Todo T
    • Journal Title

      Mutagenesis

      Volume: 28(4) Pages: 457-64

    • DOI

      10.1093/mutage/get021

  • [Journal Article] Gamma-ray irradiation promotes premature meiosis of spontaneously differentiating testis-ova in the testis of p53-deficient medak (Oryzias latipes)2012

    • Author(s)
      Yasuda T, Oda S, Li Z, Kimori Y, Kamei Y, Ishikawa T, Todo T, Mitani H
    • Journal Title

      Cell Death Dis

      Volume: 3 Pages: e395

    • DOI

      10.1038/cddis.2012.133

  • [Presentation] 福島シミュレーション実験としての137Csのマウス多世代低線量率内部被曝による子孫での生理的影響2013

    • Author(s)
      中島裕夫、本行忠志、花本敦、福角隆仁、武本憲彦、岡幸子、藤堂剛
    • Organizer
      日本環境変異原学会第42回大会
    • Place of Presentation
      岡山
    • Year and Date
      2013-11-29
  • [Presentation] Targeted Inactivation of DNA photolyase family genes using CRISPR system2013

    • Author(s)
      Tomoko Ishikawa-Fujiwara, Kumi Nakamura, Yoshihiro Fujikawa, Takeshi Todo*
    • Organizer
      The 6^<th> Asia and Oceania Conference on Photobiology
    • Place of Presentation
      Sydney (Australia)
    • Year and Date
      2013-11-11
    • Invited
  • [Presentation] Targeted Inactivation of Rev1 gene2013

    • Author(s)
      Tomoko Ishikawa-Fujiwara, Kumi Nakamura, Yoshihiro Fujikawa, Takeshi Todo
    • Organizer
      The 6^<th> Asia and Oceania Conference on Photobiology
    • Place of Presentation
      Sydney (Australia)
    • Year and Date
      2013-11-11
  • [Presentation] ゲノム編集技術(TALEN)を用いたメダカにおけるTLSポリメラーゼ変異体の網羅的作製2013

    • Author(s)
      藤川芳宏、藤原(石川)智子、中村公美、佐久間哲史2)、山本卓、藤堂剛
    • Organizer
      日本放射線影響学会第56回大会
    • Place of Presentation
      青森
    • Year and Date
      2013-10-20
  • [Presentation] Genome editing in medaka : targeted inactivation of DNA photolyase family genes using CRISPR system2013

    • Author(s)
      Tomoko Ishikawa-Fujiwara, Yoshihiro Fujikawa, Kumi Nakamura, Takeshi Todo
    • Organizer
      第19回小型魚類研究会
    • Place of Presentation
      仙台
    • Year and Date
      2013-09-20
  • [Presentation] 人工ヌクレアーゼに夜ゼブラフィッシュ培養細胞の遺伝子変異細胞の作成2012

    • Author(s)
      藤川芳宏、藤原(石川)智子、中村公美、佐久間哲史2)、山本卓、藤堂剛
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-11
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/radbio/www/index.html

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Published: 2015-06-25  

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