2013 Fiscal Year Final Research Report
Effects of Environmental Chemicals on Fetal Blood Brain Barrier
| Project/Area Number |
24651062
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 環境化学物質 / 血液脳関門 |
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| Research Abstract |
Environmental chemicals cause several adverse effects on developing brain of fetus. These effects may be caused by direct action of the chemicals to neural cells, but also there is a possibility that the effects are caused by indirect action of them, for example through disruption of blood brain barrier: BBB. In this study, we used in vitro model of BBB and analyzed the effects of the chemicals on BBB using dioxin as model chemical.
The exposure of dioxin caused a distraction of BBB permeability in dose dependently. Moreover, dioxin easily passed through BBB and increased the expression of drug metabolizing enzyme; CYP.
These results suggested that BBB disruption were caused by environmental chemicals, dioxin, and the adverse effects might cause abnormal brain development.
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