2013 Fiscal Year Final Research Report
Creation of biological-artificial hybrid rotary nanomotor
| Project/Area Number |
24651167
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Microdevices/Nanodevices
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| Research Institution | The University of Tokyo |
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Principal Investigator |
IINO Ryota 東京大学, 工学(系)研究科(研究院), 准教授 (70403003)
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| Co-Investigator(Kenkyū-buntansha) |
UCHIHASHI Takayuki 金沢大学, 数物科学系, 准教授 (30326300)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ナノマシン / 分子モーター / １分子計測 |
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| Research Abstract |
DNA-F1, a hybrid motor which has double stranded DNA as a rotor inserted into the stator ring of F1-ATPase was generated. Dependent on the energy of ATP, DNA-F1 showed stepping rotation highly biased to the one direction. Although the efficiency of the unidirectionality and the frequency of finding rotation are still low, we have achieved the first step creating hybrid rotary nanomotor. Furthermore, as a material of hybrid motor, we have constructed the single-molecule rotation assay of V1-ATPase from Enterococcus hirae and basic properties of rotary dynamics have been revealed.
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[Journal Article] Basic properties of rotary dynamics of the molecular motor Enterococcus hirae V_1-ATPase2013
Author(s)
Minagawa Y, Ueno H, Hara M, Ishizuka-Katsura Y, Ohsawa N, Terada T, Shirouzu M, Yokoyama S, Yamato I, Muneyuki E, Noji H, Murata T, Iino R
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Journal Title
J. Biol. Chem
Volume: 288
Pages: 32700-32707
DOI
Peer Reviewed
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