Identification of novel gastric systems by comparing genomic sequences between stomachless fishes and true stomach fishes

2013 Fiscal Year Final Research Report

• Project/Area Number: 24651211
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Genome biology
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: Kato Akira 東京工業大学, 生命理工学研究科, 助教 (40311336)
• Co-Investigator(Kenkyū-buntansha): 竹井 祥郎 東京大学, 大気海洋研究所, 教授 (10129249)
• Co-Investigator(Renkei-kenkyūsha): KUSAKABE Makoto 東京大学, 大気海洋研究所, 助教 (40451893) ; HIROSE Shigehisa 東京工業大学, 生命理工学研究科, 教授 (10134199)
• Research Collaborator: WATANABE Taro 東京大学, 大気海洋研究所, 技術職員 ; Romero Michael F. Mayo Clinic, Professor
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 比較ゲノム

Outline of Final Research Achievements

Some species of teleost fishes lack stomach and are called stomachless fishes. It is likely that the genomes of stomachless fishes lack genes involved in the function of the stomach and that the genes commonly deleted in stomachless fishes contain unknown gene. To understand stomachless characteristics at genome level and to identify an uncharacterized gene that is involved in known or unknown stomach function, we compared open genome resources of stomachless fishes (pufferfish, zebrafish, etc.) and true stomach fishes (stickleback, etc.). Seven genes involved in the gastric function (atp4a, atp4b, kcne2, slc26a9, vsig1, cldn18, pgc) are commonly absent in the genome databases of stomachless fishes. Stomachless fishes also lacked an uncharacterized gene, c3orf55, which is homologous to acid-activated amino-acid transporter family. This finding suggests that the novel acid-activated amino-acid transporter mediates amino-acid sensing or metabolism in the stomach.

Free Research Field

複合新領域