Chromatin loop structure prediction via fatgraph

2014 Fiscal Year Final Research Report

• Project/Area Number: 24651225
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: System genome science
• Research Institution: The University of Tokyo
• Principal Investigator: KODAMA Hiroki 東京大学, 数理(科)学研究科(研究院), 特任准教授 (40466826)
• Co-Investigator(Kenkyū-buntansha): IHARA Shigeo 東京大学, 先端科学技術研究センター, 教授 (30345136)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: トポロジー / SO(3)-接続 / ファットグラフ / 生命生体情報学 / 国際研究者交流(オーストリア) / 国際研究者交流(デンマーク)

Outline of Final Research Achievements

SO(3)-connection model of protein is a graph that each vertex is a peptide unit and on each edge rotation matrix of peptide units is given. We used this model to construct a system that visualize the difference of 3D structures of proteins. We contrived a model via Cantor set that explicates the loop structure of Chromatin. We also described pH-induced protein denaturation via grid model of protein.

Free Research Field

トポロジー