Dynamic analysis for living cell environment by 4D imaging

2014 Fiscal Year Final Research Report

• Project/Area Number: 24651229
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: System genome science
• Research Institution: Osaka University
• Principal Investigator: MATSUDA Hideo 大阪大学, 情報科学研究科, 教授 (50183950)
• Co-Investigator(Kenkyū-buntansha): SENO Shigeto 大阪大学, 大学院情報科学研究科, 助教 (30432462)
• Co-Investigator(Renkei-kenkyūsha): ISHII Masaru 大阪大学, 大学院医学系研究科, 教授 (10324758)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 細胞画像解析 / 細胞追跡 / 画像処理 / 生体イメージング

Outline of Final Research Achievements

This study aims to develop a methodology for analyzing environments of cells in living tissues by observing the time-lapse migration dynamics of the cells. For this purpose, two novel methods were developed: a method for tracking a large number of cell migrations by global data association based on a mathematical model on cell movement, and a method for identifying cell states by applying random forests to a semi-supervised classification. By using these methods to cell images, the methods demonstrated better prediction performance compared with widely-used image analysis programs.

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