A new strategy for designing mannose receptors based on enantiomers of protein domains.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24651248
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Living organism molecular science
• Research Institution: Nagoya University (2014); Institute of Physical and Chemical Research (2012-2013)
• Principal Investigator: NAKAGAWA Yu 名古屋大学, 生命農学研究科, 准教授 (90452284)
• Co-Investigator(Renkei-kenkyūsha): IRIE Kazuhiro 京都大学, 大学院農学研究科, 教授 (00168535)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 生理活性 / 蛋白質 / 糖 / 有機合成

Outline of Final Research Achievements

On the basis of the fact that L-rhamnose is equivalent to 6-deoxy-L-mannose, this study tried to synthesize an enantiomer of rhamnose-binding domains of catfish lectin SAL as a novel mannose receptor. In parallel, attempts were also made to develop a galactose receptor based on an enantiomer of PhoSL, a mushroom lectin for L-fucose, which is equivalent to 6-deoxy-L-galactose. This study aimed to propose a strategy for designing enantiomers of proteins as bioactive molecules having functions different from those of parent proteins.

Free Research Field

農学