2013 Fiscal Year Final Research Report
Generation and optimization of macrocyclic synthetic ligands through biomacromolecule-templated cyclizations
| Project/Area Number |
24651253
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical biology
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| Research Institution | Hokkaido University |
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Principal Investigator |
OGURI Hiroki 北海道大学, 理学(系)研究科(研究院), 准教授 (80311546)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | テンプレート合成 / スキャフォールド / マクロ環化 / 多官能性分子 / フラグメント |
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| Research Abstract |
This research intends to develop template-synthesis protocols for generating macrocyclic ligands as specific modulators of targeted biomacro-molecules. In this project, we have designed and synthesized densely functionalized scaffolds capable of integrating multiple functional units on the rigid skeletons. We are exploring assembly peptidyl fragments on the scaffold and subsequent macrocyclization in the presence of biomacromolecule as a template.
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