2013 Fiscal Year Final Research Report
Designing and imaging of reconstructed muscle using DNA nanostructure
| Project/Area Number |
24654139
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Biophysics/Chemical physics
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
IWAKI Mitsuhiro 独立行政法人理化学研究所, 生命システム研究センター, 上級研究員 (30432503)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ナノバイオロボティクス / DNAorigami / 人工筋肉 / メカノバイオロジー / モーター蛋白質 |
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| Research Abstract |
Our goal is to clarify the mechanism of energy-saving, flexibility and adaptability of muscle by creating an artificial muscle made of proteins and DNA molecules and observing the dynamics at the single molecule resolution.
I used DNA nanotechnology called DNAorigami and the nanosized modules were hybridized with motor protein molecules. I succeeded in constructing the artificial motor protein assembly with sub-micrometer size. Through this experiment, I confirmed the methodology for controlling the number and spacing of motor molecules. This novel methodologies enables us to analyze the emergence mechanism of unique properties of life.
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