2013 Fiscal Year Final Research Report
Analyses of plasma-biosystem interaction by PBPK model simulation
| Project/Area Number |
24654195
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Plasma science
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| Research Institution | Osaka University |
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Principal Investigator |
SATOSHI Hamaguchi 大阪大学, 工学(系)研究科(研究院), 教授 (60301826)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | プラズマ / プラズマ医療 / 生理的薬物動態モデル / ＰＢＰＫモデル / シミュレーション |
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| Research Abstract |
Physiologically based pharmacokinetic (PBPK) model is a mathematical model that describes absorption, distribution, metabolism and excretion (ADME) of chemical substances in a living body. The goal of study is to analyze plasma effects based on simulation results of reactive species (ROS/RNS) generated in liquid by plasma application and their biological effects predicted by a PBPK mode created in this study. Numerical simulations based on a PBPK model needs to be further developed due to the lack of rate constant data in literature. However, the study has deepened our qualitative understanding of the relation of plasma generated reactive species and blood coagulation processes.
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