2013 Fiscal Year Final Research Report
high-speed detection of absolute steric configuration of proteins in solution using chiral-sensitive nonlinear Raman spectroscopy
| Project/Area Number |
24655004
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical chemistry
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| Research Institution | University of Tsukuba |
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Principal Investigator |
KANO Hideaki 筑波大学, 数理物質系, 准教授 (70334240)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | キラリティ / ラマン / CARS / 非線形 |
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| Research Abstract |
In the present study, we used a new laser source, namely white-light laser source to develop a spectroscopic system which is capable of detecting molecular chirality. First, we employed spectral interferometric technique to improve the sensitivity of the system. As a result, we measured real and imaginary parts of the optical electric field due to the chiral CARS process. Next, we introduced two-color (visible and near infra-red) laser pulses into a photonic crystal fiber in order to extend spectral coverage of the white-light laser. With the use of the visible white-light laser source, we have successfully developed CARS-ROA system in visible, and found improvement of the signal-to-noise ratio.
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