2013 Fiscal Year Final Research Report

Development of novel catalytic system to synthesize delta-aminolevulinic acid

Research Project

Project/Area Number	24655033
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Single-year Grants
Research Field	Organic chemistry
Research Institution	Kobe University
Principal Investigator	MATSUBARA Ryosuke 神戸大学, 理学(系)研究科(研究院), 准教授 (90401223)
Project Period (FY)	2012-04-01 – 2014-03-31
Keywords	レブリン酸 / デルタアミノレブリン酸 / 酸化反応
Research Abstract	Levulinic acid is one of biomass compounds; many researchers are looking for effective utilization of levulinic acid. Delta-aminolevulinic acid, a derivative of levulinic acid, is known to be an important bioactive compound. In this project, we aimed for the development of novel catalytic system to enable one to synthesize delta-aminolevulinic acid directly from levulinic acid. Our first study to oxidize alpha-carbon of ketone using an oxygen radical failed, so we next tried the oxidation using an iron catalyst. During the investigation, we could develop the large-scale synthetic method of the nitrogen-containing ligand of the iron catalyst.