Preparation of immunocell-type biosensor electrodes aiming to create sensing technology for individual medicine

2015 Fiscal Year Final Research Report

• Project/Area Number: 24655055
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Analytical chemistry
• Research Institution: Akita University
• Principal Investigator: AKIBA Uichi 秋田大学, 工学(系)研究科(研究院), 准教授 (60184107)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: レドックスメディエーター / アダマンタン自己組織化単分子膜 / クリック反応 / 電極機能界面

Outline of Final Research Achievements

Two types of Ad-SAM materials with different click-reaction functionalities, azide and thiol, were synthesized in order to be efficiently modified on the surface of Ad-SAM with TEMPO-acetylene and antigen determinant derivative, respectively. Ad-SAM with azide group on the surface can be efficiently and conveniently modified with TEMPO derivative, and thus it appeared that this modification technique is extremely effective for forming various functional interfaces on electrodes. Moreover, when such an Ad-SAMs is formed using mixtures of these two types of click reactive Ad-SAM materials, various platforms of functional electrode interfaces could be easily formed on the surfaces with double click reactivity, and therefore could be available to prepare the biosensor electrodes proposed in this study.

Free Research Field

電気化学、超分子化学、ナノテクノロジー