2013 Fiscal Year Final Research Report
Catalytic Synthesis of a Chiral Silicon Center
| Project/Area Number |
24655078
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Synthetic chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
TOBISU Mamoru 大阪大学, 工学(系)研究科(研究院), 准教授 (60403143)
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| Project Period (FY) |
2012-04-01 – 2013-03-31
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| Keywords | キラルケイ素 / 触媒反応 |
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| Research Abstract |
Chemistry of chiral silicon centers remain unexplored, when compared to that of chiral carbon centers, mainly due to the lack of methods for the construction of chiral silicon centers. The purpose of this study is to develop a catalytic method for the generation of chiral silicon centers on the basis of rhodium-catalyzed synthesis of benzosiloles, which we reported previously. We found that the substrate containing an isopropyldimethylsilyl group was employed, a less bulky methyl group is cleaved exclusively, and enantioselective cleavage of two enantiotopic methyl groups was possible by adding a chiral phosphine ligand to form a benzosilole bearing a chiral silicon center.
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