Development of catalytic cross-pinacol coupling reaction based on the design of highly controlled reaction site

2014 Fiscal Year Final Research Report

• Project/Area Number: 24655079
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Synthetic chemistry
• Research Institution: Osaka University
• Principal Investigator: HIRAO Toshikazu 大阪大学, 工学(系)研究科(研究院), 教授 (90116088)
• Co-Investigator(Kenkyū-buntansha): AMAYA Toru 大阪大学, 工学研究科, 助教 (20397615)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ピナコールカップリング / 二核錯体 / 反応場 / バナジウム / チタン / ヘキサアリールベンゼン

Outline of Final Research Achievements

The reductive coupling reactions of carbonyl compounds provide an important method for the construction of a vicinally functionalized carbon-framework. However, the intermolecular cross-pinacol coupling reaction is still a challenging issue due to the difficulty in the discrimination of two aldehydes in the reaction. In this context, we envisioned that the controlled arrangement of two metals on the rigid scaffold can provide spatially regulated reaction sites for the cross-pinacol coupling reaction. As a result, intermolecular cross-pinacol coupling reaction between aliphatic and aromatic aldehydes using hetero dinuclear dihemisalen complexes with vanadium(V) and titanium(IV) on the hexaaryl benzene scaffold was achieved.

Free Research Field

有機合成化学、機能有機化学