Development of Innovative Cycloisomerization of Dienes via Chain Walking

2014 Fiscal Year Final Research Report

• Project/Area Number: 24655088
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Synthetic chemistry
• Research Institution: Keio University
• Principal Investigator: TAKUYA Kochi 慶應義塾大学, 理工学部, 講師 (70396779)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: チェーンウォーキング / 環化異性化 / パラジウム触媒 / 五員環化合物 / ジエン / 1,10-フェナントロリン配位子 / 炭素－炭素結合生成

Outline of Final Research Achievements

Chain walking is a mechanism where a metal species looks like moving around on a carbon chain and has been utilized in syntheses of polyolefins having novel structures. However, syntheses of relatively small organic molecules using this mechanism have rarely been investigated. In this research, synthesis of small organic molecules using carbon-carbon bond formation via chain walking was achieved for cycloisomerization of dienes. This reaction is applicable to various 1,n-dienes and mechanistic investigations indicated that the reaction proceeds via a chain-walking mechanism.

Free Research Field

有機金属化学、有機合成化学