Recognition of Ionic Polymers by Self-Assembled Macrocyclic Compounds

2014 Fiscal Year Final Research Report

• Project/Area Number: 24655095
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Polymer chemistry
• Research Institution: The University of Tokyo
• Principal Investigator: ITOH Yoshimitsu 東京大学, 工学(系)研究科(研究院), 助教 (00531071)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 大環状化合物 / 環状ペプチド / 超分子ポリマー / リン酸認識 / ナノチャネル

Outline of Final Research Achievements

Most of the biomolecules can be regarded as an ionic polymer. Biological events are strongly related to the recognition of those polymers by biomacromolecules. In this research, we synthesized bio-inspired peptidic macrocycles and succeeded in recognizing polymeric phosphate anion though nanotubular self-assembly. We also clarified that the polymeric phosphate anion binds to the inner cavity of the nanotube. During the investigation, we also found a preferential assembly of the same enantiomers of the peptidic macrocycles which is rarely observed in supramolecular system.

Free Research Field

有機合成化学、超分子化学