2014 Fiscal Year Final Research Report
Three-dimensional neuronal networking for regenerative medicine by active utilization of three-dimensional dynamic stimulation field
| Project/Area Number |
24656150
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dynamics/Control
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
FENG Zhonggang 山形大学, 理工学研究科, 准教授 (10332545)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 動的力学刺激 / ３次元振動ステージ / iPS細胞 / ポリ乳酸多孔質体 / 分化誘導 / ３次元ニューロンネットワーク / 再生治療 |
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| Outline of Final Research Achievements |
We have developed completely new small sized piezoelectric three-dimensional vibration stage. Together with scaffold of poly-lactic acid, the device enables us to enforce various micro dynamic stimulations upon the cultured living cells.
The system, not like a conventional approach but based on the principle of mechanics, has an ability to support development of the regenerative medicine by using iPS cells. The results suggest that utilization of appropriate dynamic stimulation may accelerate three-dimensional neuronal networking. It is also found that there may be certain correlation between the direction of the neuronal networking and the direction of the dynamic stimulation.
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| Free Research Field |
機械力学・生体力学
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