ヒト多能性幹細胞を用いた生体モデルBody on a chipの開発

Products Report

• Project/Area Number: 24656502
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Biofunction/Bioprocess
• Research Institution: Kyoto University
• Principal Investigator: KAMEI Kenichiro 京都大学, 物質ー細胞統合システム拠点, 助教 (00588262)
• Project Period (FY): 2012-04-01 – 2014-03-31

Research Products

• [Journal Article] Three-dimensional cultured liver-on-a-Chip with mature hepatocyte-like hcells derived from human pluripotent stem cells (2019)
  • Author(s): Kamei, Ken-ichiro; Yoshioka, Momoko; Terada, Shiho; Tokunaga, Yumie; Chen, Yong
  • Journal Title: Biomedical Microdevices Volume: 21 Pages: 73
  • DOI: 10.1007/s10544-019-0423-8
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Microfluidic-nanofiber hybrid array for screening of cellular microenvironments (2017)
  • Author(s): K.Kamei, Y.Mashimo, M.Yoshioka, Y.Tokunaga, C.Fockenberg, S.Terada, M.Nakajima, T.Shibata-Seki, L.Liu, T.Akaike, E.Kobatake, E.S.How, M.Uesugi and Y.Chen
  • Journal Title: Small
  • DOI: 10.1002/smll.201603104
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Integrated heart/cancer on a chip to reproduce the side effects of anti-cancer drugs in vitro (2017)
  • Author(s): Kamei, Ken-ichiro; Kato, Yoshiki; Hirai, Yoshikazu; Ito, Shinji; Satoh, Junko; Oka, Atsuko; Tsuchiya, Toshiyuki; Chen, Yong; Tabata, Osamu
  • Journal Title: RSC Advances Volume: 7 Pages: 36777-36786
  • DOI: 10.1039/C7RA07716E
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Characterization of phenotypic and transcriptional differences in human pluripotent stem cells under two- and three-dimensional culture conditions (2016)
  • Author(s): K.Kamei, Y.Koyama, Y.Mashimo, M.Yoshioka, C.Fockenberg, M.Nakashima, R.Mosbergen, O.Korn, J.Li, C.Wells and Y.Chen
  • Journal Title: Advanced Healthcare Materials Volume: 5 Pages: 2951-2958
  • DOI: 10.1002/adhm.201600893
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Development of a Body-on-a-Chip Using 3-D Microstructuring Technique (2016)
  • Author(s): Y.Kato, Y.Hirai, K.Kamei, T.Tsuchiya and O.Tabata
  • Journal Title: IEEJ Trans. SM Volume: 136 Pages: 229-236
  • DOI: 10.1541/ieejsmas.136.229
  • Peer Reviewed
• [Presentation] Bio-inspired microfluidic platform to control cell functions (2013)
  • Author(s): K.Kamei
  • Journal Title: The 10th MicRO Alliance Meeting 2013
  • Place of Presentation: 京都大学
  • Year and Date: 2013-11-21
  • Invited
• [Presentation] Engineered regulatory niche to control cellular functions (2013)
  • Author(s): K.Kamei
  • Organizer: 7th Annual Symposium on Nanobiotechnology
  • Place of Presentation: University of Bristol, Bristol, UK
  • Year and Date: 2013-11-05
  • Invited
• [Presentation] ｢Body on a Chip｣を用いた創薬スクリーニングの開発 (2013)
  • Author(s): 亀井 謙一郎
  • Organizer: テルモ科学技術振興財団 特別研究助成 贈呈式 記念講演
  • Place of Presentation: KKRホテル東京
  • Year and Date: 2013-03-14
  • Invited
• [Presentation] Nano/microengineering approach to investigate and control stem cell function (2013)
  • Author(s): K.Kamei
  • Organizer: Seminar
  • Place of Presentation: Monash University, Clayton, Australia
  • Year and Date: 2013-02-14
  • Invited
• [Presentation] Gelatin nanofibrous scaffold to maintain human ES/iPS cells for long-term period (2013)
  • Author(s): K.Kamei
  • Organizer: Joint SCA and iCeMS Symposium
  • Place of Presentation: University of Melbourne, Melbourne, Australia
  • Year and Date: 2013-02-13
  • Invited
• [Presentation] Gelatin nanofibrous scaffold enables maintaining human ES/iPS cells for long-term period (2013)
  • Author(s): K.Kamei
  • Organizer: The 1st Bristol-Kyoto Symposium 2013
  • Place of Presentation: University of Bristol, Bristol, UK
  • Year and Date: 2013-01-10
  • Invited
• [Presentation] Nanofiber scaffolds to maintain human pluripotent stem cells under feeder-free conditions (2013)
  • Author(s): K.Kamei
  • Organizer: Mini-symposium of WPI-iCeMS and Edinburgh University
  • Place of Presentation: University of Edinburgh, Edinburgh, UK
  • Year and Date: 2013-01-08
  • Invited
• [Presentation] Artificial regulatory microenvironments (niche) for controlling cell function (2012)
  • Author(s): K. Kamei
  • Organizer: IEEE Nanotechnology Material and Devices Conference (IEEE-NMDC)
  • Place of Presentation: Hawaii, USA
  • Year and Date: 20121016-20121019
  • Invited
• [Patent(Industrial Property Rights)] マイクロ流体デバイス及び細胞の微小3次元培養法 (2021)
  • Inventor(s): 亀井謙一郎、陳勇
  • Industrial Property Rights Holder: 京都大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 11130935
• [Patent(Industrial Property Rights)] マイクロ流体デバイス及び細胞の微小3次元培養法 (2019)
  • Inventor(s): 亀井 謙一郎、陳 勇
  • Industrial Property Rights Holder: 京都大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特許第6486898号
• [Patent(Industrial Property Rights)] 細胞培養足場基材、マイクロ流体デバイス及びそれを用いたハイスループットナノファイバースクリーニング方法 (2018)
  • Inventor(s): 亀井 謙一郎、眞下 泰正、劉 莉、陳 勇
  • Industrial Property Rights Holder: 京都大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 6433119
• [Patent(Industrial Property Rights)] マイクロ流体デバイス及び細胞の微小3次元培養法 (2016)
  • Inventor(s): 亀井 謙一郎, 陳 勇
  • Industrial Property Rights Holder: 京都大学
  • Industrial Property Number: 2016-505223/15/121,553/15756050.9
  • Filing Date: 2016-07-14/2016-08-25/2016-09-21
• [Patent(Industrial Property Rights)] 内胚葉系細胞の製造方法、肝臓細胞の製造方法、内胚葉系細胞の誘導促進剤、肝臓細胞の誘導促進キット、およびマイクロ流体デバイス (2015)
  • Inventor(s): 亀井 謙一郎, 本田 桃子
  • Industrial Property Rights Holder: 京都大学
  • Industrial Property Number: 国際出願PCT/JP2015/085894
  • Filing Date: 2015-12-22