2013 Fiscal Year Final Research Report
Identification and functional characterization of anandamide receptors in Caenorhabditis elegans as a model organism.
| Project/Area Number |
24657001
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 遺伝学 / 遺伝子 / シグナル伝達 / 神経科学 / 生理活性 |
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| Research Abstract |
Anandamide, a member of endocannabinoids, is known to be involved in many
physiological processes. CB1, CB2 and TRPV act as anandamide receptors in mammals. In addition, it has been suggested that mammals have an unidentified receptor CBx for anandamide. To identify new anandamide receptors, we performed a functional screening by using a nematode Caenorhabditis elegans as a model organism. As a result, we successfully identified new nematode seven-transmembrane receptors, designated as SFAH-1 and SFAH-2. SFAH-1 shows a weak similarity to CB1 and CB2 receptors, whereas SFAH-2 shows a similarity to a certain kind of vertebrate peptide receptor.
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[Journal Article] Endocannabinoid-Goαsignalling inhibits axon regeneration in Caenorhabditis elegans by antagonizing the Gqα-PKC-JNK signaling2012
Author(s)
Pastuhov, S. Iv., Fujiki, K., Nix, P., Kanao, S., Bastiani, M., Matsumoto, K., and Hisamoto, N.
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Journal Title
Nature Commun
Volume: 3
Pages: e1136
Peer Reviewed
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