2013 Fiscal Year Final Research Report
Measurement of cAMP concentration in a single neuron associated with learning
| Project/Area Number |
24657055
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
ITO Etsuro 徳島文理大学, 薬学部, 教授 (80203131)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 学習 / 記憶 / 環状アデノシン一リン酸 |
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| Research Abstract |
It has been hypothesized that cAMP concentration would be increased in a presynaptic neuron in the brain during the learning process. However, nobody has succeeded in measuring this cAMP concentration in a single neuron. To address this issue, we attempted to develop the measurement system in the key single neuron of the pond snail Lymnaea stagnalis. When we applied the super-sensitive measurement method by combination of an ELISA method and an enzymatic cycling method, we clarified that the cAMP concentration can be measured in a single neuron. We should continue to examine the change in this cAMP concentration in a single neuron in the brain by a learning procedure.
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[Journal Article] What are the elements of motivation for acquisition of conditioned taste aversion?2014
Author(s)
K.Mita, A.Okuta, R.Okada, D.Hatakeyama, E.Otsuka, M.Yamagishi, M.Morikawa, Y.Naganuma, Y.Fujito, V.Dyakonova, K.Lukowiak and E.Ito
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Journal Title
Neurobiol. Learn. Mem.
Volume: 107
Pages: 1-12
Peer Reviewed
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[Journal Article] Involvement of insulin-like peptide in long-term synaptic plasticity and long-term memory of the pond snail Lymnaea stagnalis2013
Author(s)
J.Murakami, R.Okada, H.Sadamoto, S.Kobayashi, K.Mita, Y.Sakamoto, M.Yamagishi, D.Hatakeyama, E.Otsuka, A.Okuta, H.Sunada, S.Takigami, M.Sakakibara, Y.Fujito, M.Awaji, S.Moriyama, K.Lukowiak and E.Ito
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Journal Title
J. Neurosci.
Volume: 33
Pages: 371-383
Peer Reviewed
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