2013 Fiscal Year Final Research Report
Molecular mechanism that links a nutrient-responsive miRNA with clock genes
| Project/Area Number |
24657081
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KATADA TOSHIAKI 東京大学, 薬学研究科(研究院), 教授 (10088859)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUYAMA Masamitsu 東京大学, 大学院薬学系研究科, 助教 (20422389)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | microRNA / 時計遺伝子 / 栄養感知 / 線虫 |
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| Research Abstract |
Although the microRNA (miRNA) miR-92 and its paralogues have been known to be associated with tumorigenesis, their physiological role and the signaling pathway in which they function remain to be delineated. In this study, we explored the relationship between the miR-92 family of miRNAs and the clock genes, using the nematode C. elegans and mammalian cultured cells.
We found several lines of evidence suggesting that C. elegans miR-92 orthologue, miR-235 and the clock gene Period2 ortholog lin-42 negatively regulate each other to determine the timing of differentiation in progenitor cells. On the other hand, miR-92 and one of its paralogues did not show oscillatory expression pattern in cultured rodent fibroblasts.
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Research Products
(11 results)
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[Presentation] The microRNA miR-235 suspends growth and development during starvation2013
Author(s)
Fukuyama, M., Kasuga, H., Kitazawa, A., Kume, M., Ogawa, T., Kontani, K., Katada, T.
Organizer
第46回日本発生生物学会
Place of Presentation
松江
Year and Date
2013-05-31
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