2012 Fiscal Year Final Research Report
Molecular mechanism and physiological roles of the formation and maintenance of nucleosome by circadian regulator.
| Project/Area Number |
24657084
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
HIRAYAMA Jun 東京医科歯科大学, 難治疾患研究所, 准教授 (90510363)
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| Project Period (FY) |
2012
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| Keywords | 概日リズム / クロマチン / 時計蛋白質 / ヒストンシャペロン |
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| Research Abstract |
Circadian clocks constitute ubiquitous processes that regulate various biochemical and physiological events occurring with a 24 hour periodicity. Dysfunction of these circadian rhythms can be the cause of a variety of diseases. The exact timing of this rhythm is established in cell-autonomous molecular clocks, and in mammals, the transcription factors, BMAL1, is an essential regulator of molecular clock. This study provides several lines of evidence indicating that BMAL1 may have important roles in dynamic changes ofdeposition of the specific histone, namely histone H3.3.
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