2013 Fiscal Year Final Research Report
Analysis of the regulation of asymmetric cell division by using the artificially induced polarization of HeLa cells.
Project/Area Number |
24657088
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Functional biochemistry
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Research Institution | Nagoya University |
Principal Investigator |
HANAFUSA Hiroshi 名古屋大学, 理学(系)研究科(研究院), 講師 (00345844)
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Keywords | 細胞極性 / LRRK1 / スピンドル配向 |
Research Abstract |
Asymmetric cell division is an important mechanism that regulates growth or differentiation of stem cells. In this project, we tried to reveal the role of important factors in asymmetric cell division by using the artificially induced polarization of HeLa cells, in which expressed the chimera molecules between Echinoid, an cell-cell adhesion molecule, and a factor, which activates the polarization signal pathway. We found that ROCO family kinase LRRK1 plays an important role in the control of the axis of cell division by regulating the mitotic spindle.
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