2014 Fiscal Year Final Research Report
Crosstalk between citrate sycle and gene expression system and inflammation and cancer
| Project/Area Number |
24657092
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
KAMATA hideaki 広島大学, 医歯薬保健学研究院, 准教授 (10233925)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | HIF1 / NF-kB / クエン酸回路 |
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| Outline of Final Research Achievements |
Cross talk between metabolites of citrate cycle and transcription factors including HIF-1α and NF-κB play essential role in inflammation and cancer. HIF-1α activity is regulated by protein degradation through ubiquitin proteasome system and by NF-κB-mediated transcription. Here we found that citrate suppressed translation of HIF-1α in a cell type-specific manner, and inhibited HIF-1α-mediated gene expression.
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| Free Research Field |
医化学
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