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2014 Fiscal Year Final Research Report

Crosstalk between citrate sycle and gene expression system and inflammation and cancer

Research Project

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Project/Area Number 24657092
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Functional biochemistry
Research InstitutionHiroshima University

Principal Investigator

KAMATA hideaki  広島大学, 医歯薬保健学研究院, 准教授 (10233925)

Project Period (FY) 2012-04-01 – 2015-03-31
KeywordsHIF1 / NF-kB / クエン酸回路
Outline of Final Research Achievements

Cross talk between metabolites of citrate cycle and transcription factors including HIF-1α and NF-κB play essential role in inflammation and cancer. HIF-1α activity is regulated by protein degradation through ubiquitin proteasome system and by NF-κB-mediated transcription. Here we found that citrate suppressed translation of HIF-1α in a cell type-specific manner, and inhibited HIF-1α-mediated gene expression.

Free Research Field

医化学

URL: 

Published: 2016-06-03  

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