2013 Fiscal Year Final Research Report
Regulation of pre-mRNA splicing by ribosomal proteins
| Project/Area Number |
24657116
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Molecular biology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | リボソームタンパク質 / mRNA前駆体 / 選択的スプライシング / 線虫 / 蛍光レポーター / 自己制御 / NMD |
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| Research Abstract |
Expression of eight out of ~80 ribosomal protein genes in a nematode C. elegans have been shown to be regulated at the pre-mRNA processing level. Among them, RPL-1 has been shown to directly and specifically bind to a cis-element termed L10ARE to switch the splicing pattern of its own pre-mRNA. The orthologous gene RPL10A in vertebrates has also been shown to regulate its own pre-mRNA splicing via L10ARE, demonstrating that the splicing autoregulation of the genes encoding the ribosomal protein L10A is evolutionarily conserved.
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Research Products
(16 results)
