2013 Fiscal Year Final Research Report
Functional analysis of age-associated madRNA
| Project/Area Number |
24657122
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Molecular biology
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
IIDA Tetsushi 国立遺伝学研究所, 細胞遺伝研究系, 助教 (60391851)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | RNA / 老化 / ノンコーディングRNA |
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| Research Abstract |
Asymmetric cell division, "budding", produces a virgin daughter and an older mother. Rejuvenation of the daughter in budding may be from sequestration of aging factors into the mother. In this project, we found that ribonuclease-resistant RNAs are specifically accumulated into aged mother cell.
For time-consuming process of genetic analysis, we also developed a web tool for mutation identification by next-generation sequencing.
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