2013 Fiscal Year Final Research Report
A novel type of cell death in tetraploids with chromosomal aberrations
| Project/Area Number |
24657132
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Kyoto University |
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Principal Investigator |
YONEHARA Shin 京都大学, 生命科学研究科, 教授 (00124503)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 細胞死 / 二核四倍体細胞 / eEF1A1 |
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| Research Abstract |
Abnormal chromosomal condensation induces binuclear cells with a genetically unstable tetraploidy known to facilitate aneuploid malignancies. We found such binuclear tetraploid cells to be eliminated by a novel type of programmed cell death in Chinese hamster cells. To enable various analyses of the novel cell death, we established human and mouse cell lines where the novel cell death can be induced, and then obtained exhaustive gene expression profiles from human cells before and after induction of the cell death. We found that induction of the cell death was mediated by down-regulated expression of eEF1A1 protein through accumulation of eEF1A1 mRNA into P bodies (Processing bodies), and the binding of CNBP protein to eEF1A1 mRNA was involved in this process.
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[Journal Article] Dclk1 distinguishes between tumor and normal stem cells in the intestine2013
Author(s)
Nakanishi Y, Seno H, Fukuoka A, Ueo T, Yamaga Y, Maruno T, Nakanishi N, Kanda K, Komekado H, Kawada M, Isomura A, Kawada K, Sakai Y, Yanagita M, Kageyama R, Kawaguchi Y, Taketo MM, Yonehara S, and Chiba T.
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Journal Title
Nat Genet
Volume: Vol.45
Pages: 98-103
DOI
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