2013 Fiscal Year Final Research Report
Counter ion movement during Ca2+ release
| Project/Area Number |
24657133
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 小胞体Ca2+ / カウンターイオン / TRICチャネル |
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| Research Abstract |
Although counterion movement coupled with Ca2+ release/uptake is probably required for physiologically functioning of intracellular Ca2+ stores, the molecular basis is totally unknown. We recently identified TRIC channels, that likely mediate counter-K+ currents facilitating Ca2+ release. However, TRIC-knockout mice strongly suggest the existence of other channels/transporters mediating counter currents. We attempted to find new candidates for such channels/transporters in this project, and identified Tmem52 and mitsugumin 56 from the muscle sarcoplasmic reticulum.
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[Journal Article] Trimeric intracellular cation channels and sarcoplasmic/endoplasmic reticulum calcium homeostasis2014
Author(s)
Zhou, X., Lin, P., Yamazaki, D., Park, K-H., Komazaki, S., Chen, R. S. W., Takeshima, H. & Ma, J.
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Journal Title
Circ. Res
Volume: 114
Pages: 706-716
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[Journal Article] Enhanced dihydropyridine receptor calcium channel activity improves skeletal muscle strength2013
Author(s)
Mosca, B., Bergamelli, L., Vukcevic, M, Lopez, R., Treves, S., Nishi, M., Takeshima, H., Paolini, C., Martini, M., Rispoli, G., Protasi, F. & Zorzato, F.
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Journal Title
Nat. Commun
Volume: 4
Pages: 1541
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