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2013 Fiscal Year Final Research Report

Models for connecting mechanics at cell and tissue scales

Research Project

  • PDF
Project/Area Number 24657145
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Developmental biology
Research InstitutionThe University of Tokyo

Principal Investigator

ISHIHARA SHUJI  東京大学, 総合文化研究科, 助教 (10401217)

Co-Investigator(Kenkyū-buntansha) SUGIMURA Kaoru  京都大学, 物質-細胞統合システム拠点(iCeMS), 助教 (50466033)
Project Period (FY) 2012-04-01 – 2014-03-31
Keywords発生力学 / 統計学
Research Abstract

Because of difficulty in directly measuring forces working in growing tissues, how mechanical forces are regulated for achieving deformation of animal body in their morphogenesis is still not well understood. We have developed a theoretical method for inferring the forces from shape of cells. We verified the accuracy and robustness of the method by performing comparison of our method with laser-ablation experiments, and also comparison among other inference methods. By applying our method to Drosophila epithelial tissues, we compared how mechanical features of cells in respective tissues can results in distinct and characteristic behaviors of the tissues.

  • Research Products

    (18 results)

All 2014 2013 2012 Other

All Journal Article (6 results) (of which Peer Reviewed: 5 results) Presentation (11 results) (of which Invited: 8 results) Remarks (1 results)

  • [Journal Article] The mechanical anisotropy in a tissue promotes ordering in hexagonal cell packing2013

    • Author(s)
      K. Sugimura and S. Ishihara
    • Journal Title

      Development

      Volume: 140 Pages: 4091-4101

    • DOI

      10.1242/dev.094060

    • Peer Reviewed
  • [Journal Article] Robustness of force and stress inference in an epithelial tissue2013

    • Author(s)
      K. Sugimura
    • Journal Title

      Conf Proc IEEE Eng Med Biol Soc

      Volume: 2013年号 Pages: 2712-2715

    • DOI

      10.1109/EMBC.2013.6610100

    • Peer Reviewed
  • [Journal Article] 細胞のかたちから推定する"力"の場~生き物の形づくりをベイズ統計で解き明かす2013

    • Author(s)
      石原秀至,杉村薫
    • Journal Title

      実験医学

      Volume: 31 Pages: 1232-1238

  • [Journal Article] Comparative study of non-invasive force and stress inference in tissue Eur2013

    • Author(s)
      S. Ishihara
    • Journal Title

      Phys. J. E

      Volume: 36 Pages: 45

    • DOI

      10.1140/epje/i2013-13045-8

    • Peer Reviewed
  • [Journal Article] The Drosophila actin regulator ENABLED regulates cell shape and orientation during gonad morphogenesis2012

    • Author(s)
      H. Sano
    • Journal Title

      PLoS One

      Volume: 7 Pages: e52649

    • Peer Reviewed
  • [Journal Article] Bayesian inference of force dynamics during morphogenesis2012

    • Author(s)
      S. Ishihara and K. Sugimura
    • Journal Title

      Journal of Theoretical Biology

      Volume: 313 Pages: 201-211

    • DOI

      10.1016/j.jtbi.2012.08.017

    • Peer Reviewed
  • [Presentation] Bayesian inference of forces in epitherial tissues2014

    • Author(s)
      S. Ishihara and K. Sugimura.
    • Organizer
      Workshop on Mechanics and Growth of Tissues : Development and Cancer
    • Place of Presentation
      Curie研究所(パリ,フランス)
    • Year and Date
      20140113-16
  • [Presentation] Bayesian inference of force dynamics during morphogenesis2013

    • Author(s)
      S. Ishihara and K. Sugimura.
    • Organizer
      Seminar at Paris 7
    • Place of Presentation
      パリ第7大学(パリ,フランス)
    • Year and Date
      2013-09-04
    • Invited
  • [Presentation] 形態形成の力学制御2013

    • Author(s)
      石原秀至,杉村薫
    • Organizer
      京都駅前セミナー
    • Place of Presentation
      京都キャンパスプラザ(京都市下京区)
    • Year and Date
      2013-05-17
    • Invited
  • [Presentation] Mechanical control of h exagonal cell packing in Drosophila wing2013

    • Author(s)
      石原秀至,杉村薫
    • Organizer
      東大物性研セミナー
    • Place of Presentation
      東京大学物性研(千葉県柏市)
    • Year and Date
      2013-05-14
    • Invited
  • [Presentation] 細胞の六角格子化を駆動する力学的な制御2012

    • Author(s)
      石原秀至,杉村薫
    • Organizer
      第85回日本生化学会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      20121214-16
    • Invited
  • [Presentation] Estimating the Dynamics of Forces During Morphogenesis2012

    • Author(s)
      S. Ishihara and K. Sugimura.
    • Organizer
      第50回日本生物物理学会
    • Place of Presentation
      名古屋大学(名古屋)
    • Year and Date
      20120922-24
  • [Presentation] Mechanical control of hexagonal packing in the growing Drosophila wing2012

    • Author(s)
      S. Ishihara and K. Sugimura.
    • Organizer
      EMBO Conference Series Morphogenesis and Dynamics of Multicellular Systems
    • Place of Presentation
      EMBL-Heiderberg (ドイツ、ハイデルベルグ)
    • Year and Date
      20120907-09
  • [Presentation] 変形する組織の物理特性のシステム解析2012

    • Author(s)
      石原秀至
    • Organizer
      多細胞動態の力学的制御とそのモデル化
    • Place of Presentation
      RIKEN CDB(神戸)
    • Year and Date
      20120626-27
    • Invited
  • [Presentation] Mechanical control of cell rearrangements for the developing animal forms2012

    • Author(s)
      S. Ishihara and K. Sugimura.
    • Organizer
      RIKEN QBICセミナー
    • Place of Presentation
      理研QBIC(大阪)
    • Year and Date
      2012-07-04
    • Invited
  • [Presentation] Mechanical control of cell rearrangements in the developing animal forms2012

    • Author(s)
      S. Ishihara and K. Sugimura.
    • Organizer
      京都大学理学部先端研究拠点セミナー
    • Place of Presentation
      京都大学(京都)
    • Year and Date
      2012-05-25
    • Invited
  • [Presentation] Estimating Dynamics of Forces during Morphogenesis2012

    • Author(s)
      S. Ishihara and K. Sugimura.
    • Organizer
      京都大学医学部セミナー
    • Place of Presentation
      京都大学(京都)
    • Year and Date
      2012-04-18
    • Invited
  • [Remarks] フランスキュリー研究所Y. Bellaïche、パリ第7大学F. Granerらのグループとの共同研究に発展し、また、2014年5月には組織の力測定や推定の国際ワークショップをパリ第7大学で開く(杉村、F. Granerがオーガナイザーメンバー)、国際連携としても活発な活動を行っている

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Published: 2015-06-25  

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