2013 Fiscal Year Final Research Report
Evolution of cortical intermediate progenitors and Tbr2 gene functions
| Project/Area Number |
24657158
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
NOMURA TADASHI 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (10323007)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 大脳皮質 / 中間増殖細胞 / Tbr2 / outer radial glial / 羊膜類 / 進化 |
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| Research Abstract |
To explore the evolutionary origin of mammalian intermediate progenitors, we analyzed progenitor characteristics in non-mammalian pallium. Mammalian intermediate progenitors are Tbr2-positive and undergo mitosis at the basal side of the cortex (basal progenitors: BPs). On the contrary, BPs and Tbr2-positive cells in the developing avian pallium are distinct cell population; the former resemble outer radial glial cells in primates, whereas the latter are post-mitotic neurons. Our results suggest that BPs have independently evolved in mammalian and avian lineages, which provided encephalization in these two amniote groups.
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[Journal Article] Development of the prethalamus is crucial for thalamocortical projection formation and is regulated by Olig22014
Author(s)
K. Ono, A. Clavairoly, T. Nomura, H. Gotoh, Uno, O. Armant, H. Takebayashi, Q. Zhang, K. Shimamura, S. Itohara, CM. Parras, K. Ikenaka.
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Journal Title
Development
Volume: 141
Pages: 2075-84
Peer Reviewed
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