2013 Fiscal Year Final Research Report
How does a baculovirus manipulate behavior of the host insect?
| Project/Area Number |
24658047
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Applied entomology
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
KATSUMA Susumu 東京大学, 農学生命科学研究科, 准教授 (20378863)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | バキュロウイルス / 行動 / カイコ / ptp |
|---|
| Research Abstract |
By screening Bombyx mori nucleopolyhedrovirus mutants, we identified a gene, arif-1, that is required for virus-induced abnormal behavior. The arif-1 mutants did not show any phenotypic abnormalities in cultured cells, but exhibited a strikingly low virus growth in B. mori larvae.
We also performed RNA-seq experiments using brain mRNA from healthy and virus-infected silkworms and identified more than 10 host genes of which expression was altered by virus infection. Functional analyses of these host genes are now in progress.
|
