2013 Fiscal Year Final Research Report
Studies on membrane traffic in metazoans using the silkworm mutants and the development of a new model organism for the drug discovery
| Project/Area Number |
24658048
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied entomology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SHIMADA Toru 東京大学, 農学生命科学研究科, 教授 (20202111)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 油蚕 / 尿酸顆粒 / トランスポーター / BLOC複合体 / リソソーム関連オルガネラ (LRO) |
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| Research Abstract |
The gene responsible for ov (mottled translucent of Var) and ovp (ov of pinhead) was identified by positional cloning based on the genome information, and was revealed to be Bmdysb, encoding the Dysbindin, a subunit of BLOC-1, a protein complex required for formation of lysosome-related organelles (LROs). The transcription of Bmdysb was drastically reduced in ov and ovp. Other larval translucent mutants, obt and otm were also investigated. These mutants were caused by the genes encoding different subunits of BLOC-1, respectively. Therefore, it is concluded that the subunits of BLOC-1 play crucial roles in formation of urate granules in the cells of larval epidermis of the silkworm.
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Research Products
(11 results)
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[Journal Article] Mutation of a novel ABC transporter gene is responsible for the failure to incorporate uric acid in the epidermis of ok mutants of the silkworm, Bombyx mori2013
Author(s)
Lingyan Wang, Takashi Kiuchi, Tsuguru Fujii, Takaaki Daimon, Muwang Li, Yutaka Banno, Shingo Kikuta, Takahiro Kikawada, Susumu Katsuma, and Toru Shimada
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Journal Title
Insect Biochemistry and Molecular Biology
Volume: 43 (7)
Pages: 562-571
DOI
Peer Reviewed
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