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2013 Fiscal Year Final Research Report

Analysis and application of lipid metabolisms in anaerobic bacteria for reducing trans fatty acid in foods derived from ruminant animals

Research Project

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Project/Area Number 24658079
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Applied microbiology
Research InstitutionKyoto University

Principal Investigator

OGAWA Jun  京都大学, (連合)農学研究科(研究院), 教授 (70281102)

Co-Investigator(Kenkyū-buntansha) ANDO Akinori  京都大学, 生理化学研究ユニット, 助教 (10537765)
KISHINO Shigenobu  京都大学, 大学院農学研究科, 助教 (40432348)
Project Period (FY) 2012-04-01 – 2014-03-31
Keywordsトランス脂肪酸 / 嫌気性微生物 / 飽和化 / 反芻動物 / FAD / NADH / オレイン酸 / 乳酸菌
Research Abstract

Trans fatty acids in foods are reported to have bad effects on health. Trans fatty acids are found in foods derived from ruminant animals such as cow and sheep. Low trans fatty acid is recommended for health. In this research, it was found that hydratase catalyzing the first step of the polyunsaturated fatty acid saturation metabolism is involved in trans fatty acid generating systems. The ratio of cis/trans fatty acid was influenced by the activity control of the hydratase.

  • Research Products

    (12 results)

All 2013 2012 Other

All Journal Article (7 results) (of which Peer Reviewed: 3 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Hydroxy fatty acid production by Pediococcus sp2013

    • Author(s)
      Takeuchi, M., S. Kishino, K. Tanabe, Hirata, S.B. Park, S. Shimizu, J. Ogawa
    • Journal Title

      Eur. J. Lipid Sci. Technol

      Volume: 115 (4) Pages: 386-393

    • DOI

      10.1002/ejlt.201200414

    • Peer Reviewed
  • [Journal Article] Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition2013

    • Author(s)
      Kishino, S., M. Takeuchi, S.B Park, A. Hirata, N. Kitamura, J. Kunisawa, H. Kiyono, R. Iwamoto, Y.Isobe, M. Arita, H. Arai, K. Ueda, J. Shima, S. Takahashi, K. Yokozeki, S. Shimizu, J. Ogawa
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 110 (44) Pages: 17808-17813

    • DOI

      10.1073/pnas.1312937110/-/DCSupplemental

    • Peer Reviewed
  • [Journal Article] 乳酸菌の新たな脂肪酸代謝―機能性脂肪酸生産と腸内脂質代謝制御への展開2013

    • Author(s)
      岸野重信,小川順
    • Journal Title

      化学と生物

      Volume: 51 (11) Pages: 738-744

  • [Journal Article] 乳酸菌における不飽和脂肪酸の飽和化反応に関わる新規酵素群の機能解析2013

    • Author(s)
      岸野重信,小川順
    • Journal Title

      バイオサイエンスとインダストリー

      Volume: 71 (2) Pages: 134-137

  • [Journal Article] 「特集 : 美味しい健康生活は微生物が作る~作物生産、食品素材開発、健康支援~」乳酸菌代謝と美味しい健康生活2013

    • Author(s)
      小川順,岸野重信
    • Journal Title

      生物工学会誌

      Volume: 91 (11) Pages: 637-640

  • [Journal Article] 腸内細菌に特異な脂質代謝「脂肪酸飽和化反応」に関与する新規酵素系の機能解析と応用2013

    • Author(s)
      小川順
    • Journal Title

      日本応用酵素協会誌

      Volume: 48 Pages: 47-48

  • [Journal Article] Polyunsaturated fatty acid production and transformation by Mortierelia alpina and anaerobic bacteria2012

    • Author(s)
      Ogawa, J., E. Sakuradani, S. Kishino, A. Ando, K. Yokozeki, S. Shimizu
    • Journal Title

      Eur. J. Lipid Sci. Technol

      Volume: 114 (10) Pages: 1107-1113

    • DOI

      10.1002/ejlt.201200069

    • Peer Reviewed
  • [Presentation] Development of platform technologies and screening of module enzymes for multi-component enzyme systems requiring energy supply2013

    • Author(s)
      Ogawa, J., S. Kishino, M. Hibi, N. Horinouchi, K. Yokozeki, S. Takahashi, S. Shimizu
    • Organizer
      Enzyme Engineering XXII
    • Place of Presentation
      Toyama, Japan
    • Year and Date
      20130922-26
  • [Presentation] Enzymatic chiral alcohol synthesis using oxygenases and hydratases2013

    • Author(s)
      Ogawa, J., M. Hibi, S. Kishino, S. Shimizu
    • Organizer
      17^<th> German-Japanese Workshop on Enzyme Technology
    • Place of Presentation
      Hamburg, Germany
    • Year and Date
      20130726-27
  • [Presentation] Development of multi-component enzyme systems for future chemical industry2013

    • Author(s)
      Ogawa, J., M. Hibi, S. Kishino, N. Horinouchi, A. Ando, E. Sakuradani, S. Shimizu
    • Organizer
      2013 KSBB Spring Meeting and International Symposium
    • Place of Presentation
      Gwangju, Korea
    • Year and Date
      20130410-12
  • [Presentation] Lactobacillus plantarum AKU 1009a由来リノール酸水和酵素の諸性質解明2013

    • Author(s)
      竹内道樹,田辺香緒里,平田晶子,朴時範,岸野重信,小川順
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      仙台
    • Year and Date
      20130324-28
  • [Remarks]

    • URL

      http://www.hakko.kais.kyoto-u.ac.jp/

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Published: 2015-06-25  

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