Elucidation of mechanisms to avoid chronic inflammation via enteroendocrine system: relationships between immune cells and adipocytes

2014 Fiscal Year Final Research Report

• Project/Area Number: 24658114
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Food science
• Research Institution: Hokkaido University
• Principal Investigator: ISHIZUKA Satoshi 北海道大学, (連合)農学研究科(研究院), 准教授 (00271627)
• Co-Investigator(Renkei-kenkyūsha): HIRA Tohru 北海道大学, 大学院農学研究院, 講師 (10396301)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: chronic inflammation

Outline of Final Research Achievements

Diet-induced obesity induces chronic inflammation. At postplandial period, various external antigens other than dietary lipids get into lymph ducts and evoke immune responses. In this study, we evaluated factors in lymph ducts by using lymph-cannulated rats especially at a postplandial period. At several hours after administration of dietary lipids, there was a significant increase of interleukin-6(IL-6) and glucagon-like peptide-1 in the lymph. Gene expression analysis in food-deprived or fed rats indicated that an accumulation of IL-6 producing cells in the intestinal mucosa accompanied by lipid absorption.

Free Research Field

食品栄養学